# scientific method

**URL:** https://discourse.datamethods.org/c/edu/scimeth/49.md

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## [About the scientific method category](https://discourse.datamethods.org/t/about-the-scientific-method-category/72)

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**Author:** [@f2harrell](https://discourse.datamethods.org/u/f2harrell)\
**Replies:** 0

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Learning and teaching about the scientific method and experimental design

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## ["Amazing findings in medicine are sometimes based on one patient" — Paul Hwang](https://discourse.datamethods.org/t/amazing-findings-in-medicine-are-sometimes-based-on-one-patient-paul-hwang/7068)

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**Author:** [@davidcnorrismd](https://discourse.datamethods.org/u/davidcnorrismd)\
**Replies:** 0\
**Last updated:** [September 18, 2023, 10:51am UTC](https://discourse.datamethods.org/t/amazing-findings-in-medicine-are-sometimes-based-on-one-patient-paul-hwang/7068 "2023-09-18T10:51:00Z")

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Ironic story of lawyer with chronic fatigue who went back to school for an MPH “to understand biostatistics on the path to understanding herself,” but who ultimately was diagnosed by what sounds like N-of-1 bench science…

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## [Science Magazine: Neuroscientist finds signs of fabrication in scores of Alzheimer's articles](https://discourse.datamethods.org/t/science-magazine-neuroscientist-finds-signs-of-fabrication-in-scores-of-alzheimers-articles/5836)

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**Author:** [@R\_cubed](https://discourse.datamethods.org/u/R_cubed)\
**Replies:** 1\
**Last updated:** [July 25, 2022, 1:24pm UTC](https://discourse.datamethods.org/t/science-magazine-neuroscientist-finds-signs-of-fabrication-in-scores-of-alzheimers-articles/5836 "2022-07-25T13:24:50Z")

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I happened to be scanning the links on Hacker News and found this very interesting (and shocking) article. This opens up a Pandora’s Box of difficult questions for research synthesis and meta-analysis.

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## [Significance tests, p-values, and falsificationism](https://discourse.datamethods.org/t/significance-tests-p-values-and-falsificationism/4738)

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**Author:** [@PeterM](https://discourse.datamethods.org/u/PeterM)\
**Replies:** 100\
**Last updated:** [September 23, 2021, 9:06pm UTC](https://discourse.datamethods.org/t/significance-tests-p-values-and-falsificationism/4738 "2021-09-23T21:06:38Z")

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This thread takes its inspiration from the recent discussions in social science and statistics about significance tests, what they’re good for, whether p-values should be banned, and what all of that has to do with gener…