# Substituting treatment arm with drug exposure (continuous variable) in RCT

**URL:** <https://discourse.datamethods.org/t/substituting-treatment-arm-with-drug-exposure-continuous-variable-in-rct/7327>\
**Category:** research methods\
**Tags:** rct\
**Created:** [December 29, 2023, 4:47pm UTC](https://discourse.datamethods.org/t/substituting-treatment-arm-with-drug-exposure-continuous-variable-in-rct/7327 "2023-12-29T16:47:59Z")\
**Posts on this page:** 1\
**Showing post:** 6

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**Author:** ![f2harrell](https://discourse.datamethods.org/user_avatar/discourse.datamethods.org/f2harrell/32/165_2.png) [@f2harrell](https://discourse.datamethods.org/u/f2harrell)\
**Post date:** [January 3, 2024, 7:28am UTC](https://discourse.datamethods.org/t/substituting-treatment-arm-with-drug-exposure-continuous-variable-in-rct/7327/6 "2024-01-03T07:28:20Z")

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I think there is some small risk of a collider bias, which is why dose-response analysis (dose vs. clinical outcomes) is emphasized. But the analyses incorporating achieved blood concentration will be extremely helpful.

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