# \#dose-escalation

**URL:** https://discourse.datamethods.org/tag/dose-escalation/145.md

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## [Anomal Pharm: Randomized good, statistical bad](https://discourse.datamethods.org/t/anomal-pharm-randomized-good-statistical-bad/5086)

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**Author:** [@davidcnorrismd](https://discourse.datamethods.org/u/davidcnorrismd)\
**Replies:** 2\
**Last updated:** [November 24, 2021, 3:51pm UTC](https://discourse.datamethods.org/t/anomal-pharm-randomized-good-statistical-bad/5086 "2021-11-24T15:51:13Z")

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The 2021 Friends of Cancer Research Annual Meeting Day 2 featured a panel discussion somehow connected with FDA’s #ProjectOptimus, in which the supposed importance of randomized dose-comparison studies was stressed, but …

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## [Early phase dose finding studies - inviting perspectives on 3+3 versus dose titration](https://discourse.datamethods.org/t/early-phase-dose-finding-studies-inviting-perspectives-on-3-3-versus-dose-titration/4610)

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**Author:** [@karlamoPA](https://discourse.datamethods.org/u/karlamoPA)\
**Replies:** 8\
**Last updated:** [July 24, 2021, 1:31pm UTC](https://discourse.datamethods.org/t/early-phase-dose-finding-studies-inviting-perspectives-on-3-3-versus-dose-titration/4610 "2021-07-24T13:31:21Z")

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3+3 dose level groups versus individualized dose titration: Which approach maximizes the prospect for clinical benefit (a core principle for ethical clinical research) – arguably, in my view, the reason most patients t…

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## [Type I error in a specific design of 2-parallel group study](https://discourse.datamethods.org/t/type-i-error-in-a-specific-design-of-2-parallel-group-study/3051)

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**Author:** [@BertrandBio](https://discourse.datamethods.org/u/BertrandBio)\
**Replies:** 3\
**Last updated:** [March 11, 2020, 3:35pm UTC](https://discourse.datamethods.org/t/type-i-error-in-a-specific-design-of-2-parallel-group-study/3051 "2020-03-11T15:35:07Z")

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Hello, There’s this clinical trial where the study drug was tested with the following scheme: 1 substudy where the study drug was compared to a placebo comparator (both flat-dosed), & another substudy within the same tr…