# \#multiple-endpoints **URL:** https://discourse.datamethods.org/tag/multiple-endpoints/142.md [Latest](https://discourse.datamethods.org/latest.md) · [Categories](https://discourse.datamethods.org/categories.md) · [Tags](https://discourse.datamethods.org/tags.md) --- ## [Question on the Use of Composite Outcomes vs. All-Cause Mortality in Drug Trials](https://discourse.datamethods.org/t/question-on-the-use-of-composite-outcomes-vs-all-cause-mortality-in-drug-trials/28101)
**Author:** [@DylanArmbruster](https://discourse.datamethods.org/u/DylanArmbruster)\ **Replies:** 9\ **Last updated:** [May 21, 2025, 10:09am UTC](https://discourse.datamethods.org/t/question-on-the-use-of-composite-outcomes-vs-all-cause-mortality-in-drug-trials/28101 "2025-05-21T10:09:04Z")
Hello, I’ve looked through previous discussions but haven’t found one that directly addresses this issue. I’ve come across arguments suggesting that composite outcomes, especially those including all-cause mortality (AC… --- ## [Progression in cancer trials](https://discourse.datamethods.org/t/progression-in-cancer-trials/6485)
**Author:** [@sme](https://discourse.datamethods.org/u/sme)\ **Replies:** 26\ **Last updated:** [June 25, 2024, 6:47pm UTC](https://discourse.datamethods.org/t/progression-in-cancer-trials/6485 "2024-06-25T18:47:13Z")
I would love to start a conversation regarding analysis of progression in cancer studies. I can see a few issues with the types of measure used and how they are analysed. For a little background, a typical study in my ar… --- ## [Handling missing continuous data due to death](https://discourse.datamethods.org/t/handling-missing-continuous-data-due-to-death/7437)
**Author:** [@timdisher](https://discourse.datamethods.org/u/timdisher)\ **Replies:** 7\ **Last updated:** [February 8, 2024, 9:57pm UTC](https://discourse.datamethods.org/t/handling-missing-continuous-data-due-to-death/7437 "2024-02-08T21:57:35Z")
Hi everyone, I work in neonatal research where it’s common to have interventions that have large benefits to the in-hospital course but heterogeneous outcomes in terms of development. So for example we can reduce lung d… --- ## [Summary Statistics vs Raw Data](https://discourse.datamethods.org/t/summary-statistics-vs-raw-data/4165)
**Author:** [@f2harrell](https://discourse.datamethods.org/u/f2harrell)\ **Replies:** 9\ **Last updated:** [October 23, 2023, 2:32pm UTC](https://discourse.datamethods.org/t/summary-statistics-vs-raw-data/4165 "2023-10-23T14:32:24Z")
The purpose of this topic is for clinical trialists and statisticians to discuss power, sample size, missing data-handling, and treatment \\times time interaction advantages of using longitudinal raw data in analyzing pa… --- ## [Clinical Trial Outcomes Interrupted by Other Outcomes](https://discourse.datamethods.org/t/clinical-trial-outcomes-interrupted-by-other-outcomes/4475)
**Author:** [@f2harrell](https://discourse.datamethods.org/u/f2harrell)\ **Replies:** 19\ **Last updated:** [June 13, 2021, 6:33pm UTC](https://discourse.datamethods.org/t/clinical-trial-outcomes-interrupted-by-other-outcomes/4475 "2021-06-13T18:33:52Z")
This is a discussion of how best to analyze and to present clinical outcomes when an outcome of major interest can be interrupted by another outcome making the first outcome unobservable. The most common example is when… --- ## [Ordinal outcomes in survival analysis](https://discourse.datamethods.org/t/ordinal-outcomes-in-survival-analysis/4054)
**Author:** [@ulfham](https://discourse.datamethods.org/u/ulfham)\ **Replies:** 3\ **Last updated:** [January 15, 2021, 10:09pm UTC](https://discourse.datamethods.org/t/ordinal-outcomes-in-survival-analysis/4054 "2021-01-15T22:09:57Z")
Frank Harrell has a very interesting idea in his talk “Ways to Make Randomized Clinical Trials More Statistically Efficient”, using random effects ordinal logistic models to analyze an ordinal survival outcome (for examp… --- ## [Recurrent event model for non-fatal event using EHR data](https://discourse.datamethods.org/t/recurrent-event-model-for-non-fatal-event-using-ehr-data/3822)
**Author:** [@KAMRAN\_KHAN](https://discourse.datamethods.org/u/KAMRAN_KHAN)\ **Replies:** 4\ **Last updated:** [October 7, 2020, 5:21pm UTC](https://discourse.datamethods.org/t/recurrent-event-model-for-non-fatal-event-using-ehr-data/3822 "2020-10-07T17:21:03Z")
Does anyone know of a paper about using EHR events as proxy state for a multi-state recurrent event survival modelling approach? Thank you --- ## [Multiple test correction for several independent DVs?](https://discourse.datamethods.org/t/multiple-test-correction-for-several-independent-dvs/3770)
**Author:** [@JacobRitchie](https://discourse.datamethods.org/u/JacobRitchie)\ **Replies:** 1\ **Last updated:** [September 23, 2020, 2:04pm UTC](https://discourse.datamethods.org/t/multiple-test-correction-for-several-independent-dvs/3770 "2020-09-23T14:04:49Z")
Hi, A researcher I know recently was asked by a reviewer to correct their results for multiple comparisons. They ran four linear regression models with the same data for the independent variables (the same 4 IVs in eac… --- ## [Presenting models of multiple (potentially recurring) outcomes](https://discourse.datamethods.org/t/presenting-models-of-multiple-potentially-recurring-outcomes/3078)
**Author:** [@Krzysztof\_Sakrejda](https://discourse.datamethods.org/u/Krzysztof_Sakrejda)\ **Replies:** 1\ **Last updated:** [March 6, 2020, 11:08am UTC](https://discourse.datamethods.org/t/presenting-models-of-multiple-potentially-recurring-outcomes/3078 "2020-03-06T11:08:03Z")
In an earlier discussion of multiple recurring outcomes within patients, Frank Harrell made a comment (quoted below) that I want to promote to a topic and add to. Here’s the core part of Frank’s comment: Another contr…