# \#safety

**URL:** https://discourse.datamethods.org/tag/safety/99.md

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## [Methodology: Benefit Risk Assessment when Risk and Benefit are only observed in different timing](https://discourse.datamethods.org/t/methodology-benefit-risk-assessment-when-risk-and-benefit-are-only-observed-in-different-timing/5457)

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**Author:** [@Mengchun\_Li](https://discourse.datamethods.org/u/Mengchun_Li)\
**Replies:** 5\
**Last updated:** [April 18, 2022, 1:00pm UTC](https://discourse.datamethods.org/t/methodology-benefit-risk-assessment-when-risk-and-benefit-are-only-observed-in-different-timing/5457 "2022-04-18T13:00:50Z")

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In the FDA benefit risk guidance (2021) the following point was mentioned: “The time course over which the benefits and risks occur (e.g., considering adverse events that may occur shortly after initiation for benefits t…

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## [Proposal for a different way to analyze multivariate treatment safety outcomes](https://discourse.datamethods.org/t/proposal-for-a-different-way-to-analyze-multivariate-treatment-safety-outcomes/923)

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**Author:** [@f2harrell](https://discourse.datamethods.org/u/f2harrell)\
**Replies:** 0\
**Last updated:** [November 11, 2018, 4:35pm UTC](https://discourse.datamethods.org/t/proposal-for-a-different-way-to-analyze-multivariate-treatment-safety-outcomes/923 "2018-11-11T16:35:51Z")

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As discussed recently on twitter there is a great deal of uncertainty in the clinical trial community about how to assess treatment safety when there are numerous possible adverse events to monitor. One of the most prom…