# \#sequential

**URL:** https://discourse.datamethods.org/tag/sequential/115.md

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## [Alpha spending/information fraction when controlling for baseline covariate](https://discourse.datamethods.org/t/alpha-spending-information-fraction-when-controlling-for-baseline-covariate/25545)

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**Author:** [@martinmodrak](https://discourse.datamethods.org/u/martinmodrak)\
**Replies:** 2\
**Last updated:** [January 29, 2025, 10:52pm UTC](https://discourse.datamethods.org/t/alpha-spending-information-fraction-when-controlling-for-baseline-covariate/25545 "2025-01-29T22:52:01Z")

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I am helping with a statistical analysis plan for an RCT. We want to control for the outcome variable at baseline and also use sequential analysis with alpha spending. Sequential designs are new to me so I am trying to r…

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## [Logistics of treatment effect estimation with interim analyses](https://discourse.datamethods.org/t/logistics-of-treatment-effect-estimation-with-interim-analyses/5720)

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**Author:** [@PaulGS](https://discourse.datamethods.org/u/PaulGS)\
**Replies:** 1\
**Last updated:** [June 1, 2022, 12:52pm UTC](https://discourse.datamethods.org/t/logistics-of-treatment-effect-estimation-with-interim-analyses/5720 "2022-06-01T12:52:43Z")

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These are probably simple concepts for you guys but I am trying to understand the practicalities of analysing data from a group-sequential design where the outcome is continuous and you plan to measure each participant a…

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## [Adding new sites to Bayesian hierarchical model when analyzing data sequentially](https://discourse.datamethods.org/t/adding-new-sites-to-bayesian-hierarchical-model-when-analyzing-data-sequentially/3757)

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**Author:** [@sscogges](https://discourse.datamethods.org/u/sscogges)\
**Replies:** 1\
**Last updated:** [September 21, 2020, 6:46pm UTC](https://discourse.datamethods.org/t/adding-new-sites-to-bayesian-hierarchical-model-when-analyzing-data-sequentially/3757 "2020-09-21T18:46:30Z")

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Suppose I’m analyzing data sequentially using a Bayesian statistical model. The data are clustered by site, so the model includes a hierarchical component for site. In addition, suppose that some sites may take longer th…

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## [Bayesian Power: No Unobservables](https://discourse.datamethods.org/t/bayesian-power-no-unobservables/1849)

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**Author:** [@f2harrell](https://discourse.datamethods.org/u/f2harrell)\
**Replies:** 6\
**Last updated:** [July 8, 2019, 6:16pm UTC](https://discourse.datamethods.org/t/bayesian-power-no-unobservables/1849 "2019-07-08T18:16:17Z")

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Most statisticians I’ve spoken with who frequently collaborate with investigators in doing frequentist power calculations believe that the process is nothing more than a game or is voodoo. Minimal clinically important e…

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## [How to use p-values when sample sizes are not fixed](https://discourse.datamethods.org/t/how-to-use-p-values-when-sample-sizes-are-not-fixed/1395)

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**Author:** [@pieter](https://discourse.datamethods.org/u/pieter)\
**Replies:** 5\
**Last updated:** [March 1, 2019, 11:09am UTC](https://discourse.datamethods.org/t/how-to-use-p-values-when-sample-sizes-are-not-fixed/1395 "2019-03-01T11:09:05Z")

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Scenario: a minimum sample size is calculated a digital survey is opened, parcipants are invited to fill it in procedure: “We’ll have the survey open for 30 days and stop then, unless there’s insufficient response, in …

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## [Interim Analysis & "Alpha Spending" in RCT's using Bayesian Analyses](https://discourse.datamethods.org/t/interim-analysis-alpha-spending-in-rcts-using-bayesian-analyses/1259)

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**Author:** [@ADAlthousePhD](https://discourse.datamethods.org/u/ADAlthousePhD)\
**Replies:** 15\
**Last updated:** [January 25, 2019, 1:42pm UTC](https://discourse.datamethods.org/t/interim-analysis-alpha-spending-in-rcts-using-bayesian-analyses/1259 "2019-01-25T13:42:56Z")

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Some folks already know - I’m a trained frequentist statistician that’s become progressively more Bayesian by philosophy, though my technical knowledge is still very much a work in progress, and many of the trials that I…