If you read this thread you will not be surprised that the leaders have NOW suggested that the SOFA score needs to be updated (after 25 years). The “need for update” of SOFA is discussed here… .
Changing SOFA would presumably change the criteria for RCT of the “Synthetic Syndrome” of sepsis and which is based on the old 1996 SOFA. A discussion of RCT of synthetic syndromes is provided here.
. …The End of the "Syndrome" in Critical Care
SIRS the old threshold set for sepsis was guessed in 1989 and was the core of the sepsis criteria for RCT (with updates every decade until 2015 when it was abandoned and replaced by SOFA…) As expected given the use of guessed thresholds as measurements to define the synthetic syndrome, no positive sepsis RCT has been reproducible for 30 years.
There is a common theme here discussed in the sister thread.----guessing and updating RCT measurements has replaced discovery. No need for discovery of measurements when you can guess and update them and do RCT.
So, it was predictable that an update of SOFA, like those which which were guessed every decade of the sepsis criterial with SIRS. These updates are widely cited at the apex of another decade of RCT…
This is “science” by administration not discovery… Statistician beware…
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