I am an epidemiologist with a substantive research interest in cognitive aging, dementia and aging and mental health. I conduct research in dementia, delirium, cognitive aging, and cognitive or brain reserve. I have a special interest in the effect of environmental and experiential influences on adult cognitive development. My main methods research is directed at the application of psychometric and latent variable models such as item response theory and structural equation models in the area of cognitive reserve, cognitive aging and dementia. I am the Director of the Quantitative Science core at Brown. This is a service core serving the Department of Psychiatry and Human Behavior, the Department of Neurology, the Norman Prince Neuropsychiatric Institute of Rhode Island Hospital, and the VA Center of Excellence for Neurorestoration and Neurotechnology of the Providence Veterans Administration Medical Center. I am a senior associate editor for Alzheimer’s & Dementia: Diagnosis and Disease Monitoring, biostatistics editor for Alzheimer’s & Dementia, and as an assistant editor for biostatistics at the Journal of the American Geriatrics Society.