I would like to see if a type of dental restoration on temporary teeth has the side effect of accelerating the exfoliation of the temporary tooth. For this purpose, I am designing an observational split-mouth study where a tooth with the restoration will be with its counterpart, that is, the tooth on the other side without the restoration (split-mouth design).
It would be fantastic to receive some expert comments about:
is it OK to make an estimate of the sample size as shown with R ?
gsDesign::nSurvival(lambda1=.1 , ## hazard rate control (no restoration) lambda2=.25, ## hazard rate restoration group, less since I expect "less" survival, i.e. earlier exfoliation time eta = .1, ## equal drop out rate for both groups Ts = 9, ## maximum study duration in months Tr = 3, ## accrual (recruitment) duration in months sided=1, alpha=.025, ratio = 1, beta = .2); ss # default values
Which approach do you recommend for the analysis considering the fact that the units (teeth) are not independent? My idea is to perform a survival analysis and determine whether or not the restoration with this particular material accelerates the exfoliation of the temporary teeth.
Thanks in advance!