CAR T Cells - Major Challenges (Data Analysis/Models, Data Analysis/Modeling Strategy)

Major challenges:

“(1) Various non-proportional hazards patterns manifested in CAR-T trials violate the proportional hazards assumption, resulting in underpowered studies conducted in the conventional fashion. How can a novel study design salvage the power loss?

(2) How can the manufacturing process and trial eligibility criterion be improved via artificial intelligence and machine learning?”


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