Clinicians increased awareness of RCT structure

[llynn]

https://x.com/PulmCrit/status/2083172664173031665?s=20

Note the clinicians are increasingly aware of the structural flaws of fake measurements as RCT entry criteria and outcomes. This is a causal integrity RCT (a CIR) but with a guessed standard composite outcome. Clinicians are now enlightened and have learned to look beyound internal validity. Pathological RCT design no longer passes the increased awareness of clinicians of RCT structural flaws.

We are witnessing a progressive decline in deference to the expertise in RCT design once given, with great trust, to Trialists and statisticians. This will only get worse until RCT causal structure becomes a central consideration of RCT design.

I warned about this 6 years ago. Time to listen.

What is a fake measurement tool and how are they used in RCT

I have linked an article below published this month. This provides more evidence that the measurement tools used for critical care RCT esp. for sepsis and mortality are often fake. Those who have studied this issue did not need more evidence but perhaps if enough of these studies are published the perceived bright star of SOFA will fade (as SIRS has faded). This study is no surprise given there has not been a single reproducibly positive sepsis RCT for 30 yrs. Now fake is a harsh word and I d…