Covariate adjustment in non-inferiority trials

Dear all,
I am looking for guidance on covariate adjustment in non-inferiority trials with a binary outcome. In a superiority trial, covariate adjustment leads to gain in power. The treatment coefficient moves away from 0. But this appears to lead to loss in power in non-inferiority trials. Does this mean we should not adjust for covariates in non-inferiority trials? I am wondering if there any guidance on this, and what are your recommendations for this situation. Many thanks.

The only reason for choosing a less powerful method is to not be seeking the truth. Not a good strategy IMHO.

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Many thanks Frank. I agree that one should chose the strategy that maximizes power.

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covariates would have to be prespecified and i think ich e9 says you shouldnt nominate too many of them

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