Finding a cut-off for skewed biomarker in predicting death/recurrence

[R_cubed]

Check out chapters 18 and 19 of Biostatistics for Biomedical Research on the risk modelling analysis alternative to your problem. So-called “cut points” will not reproduce and lose information contained in the data collected.

See also:

Association of continuous outcomes with binary endpoints; and "optimal" cut-off points

Hello, everyone. A frequent type of problem that I deal with in my work can be characterized as follows: 1) I have some observational data that is obtained from various hospital records, 2) The primary exposure of interest is some intraoperative continuous measure such as heart rate or blood pressure, 3) The outcome is some sort of postoperative complication (e.g. postoperative delirium) and is usually binary, 4) The researchers are usually interested in characterizing the association between th…