Generalizability vs. Transportability in Trials

Suhail- I think you’re trying to create a disagreement where there is none :slightly_smiling_face:. I agree with everything you’ve written here! But “NNT”=1/ARR and ARR will change from trial to trial, so I’m just saying that the notion that there’s “one true NNT to rule them all” for a given therapy is misguided. Therefore, we shouldn’t be using “NNT” to decide whether it’s worthwhile to apply a therapy to an individual patient…

Okay now I get your point: The RD (aka ARR) and its transforms are point of care measures of applicability and are not considered trial specific measures even when reported in trials and are therefore not usually meta-analyzed except in error.