RMS Discussions

[pmbrown]

many thanks. I believe this is the study i was searching for:

A randomized trial of epinephrine in out-of-hospital cardiac arrest

GD Perkins et al presented an extremely well designed and conducted double blind randomized trial of epinephrine vs. placebo, randomizing over 8,000 patients. The primary outcome was the probability of survival at 30 days. Secondary outcomes included the probability of survival until hospital discharge with a score of 3 or less on the modified Rankin scale (which ranges from 0 [no symptoms] to 6 [death]). The statistical analysis was state-of-the-art, including an ordinal analysis with the pro…

https://www.nejm.org/doi/full/10.1056/NEJMoa1806842