So I’m doing a meta-analysis for the first time and I’m trying to get through some new (to me) statistical techniques using R. To test whether I’m used the code correctly, I’ve been using a few of the studies absolute data and calculating the stats and checking if I get the same results as reported in the studies. However, I keep getting slightly different results and I’m wondering why.

Is this normal? Using the same test but different software and getting slightly different results?

For Example:

When I use R, I get a RR of 0.51 (0.36-0.72) using the code below:

library(epiR)

RiskFactor <- matrix(c(28, 103, 253, 351), ncol=2, byrow = TRUE)

colnames(RiskFactor) <- c(‘Infection’, ‘NoInfection’)

rownames(RiskFactor) <- c(‘LiverDis’, ‘NoLiverDisease’)

RiskFactor <- as.table(RiskFactor)RiskFactor

epi.2by2(RiskFactor, method=“cohort.count”)

Could I ask a few of you experts to use your stats tool of choice to compare?