There are a growing number of research papers that are proposing the use of the “Fragility Index” to be published alongside RCTs. Unsurprisingly, when this has been investigated in surgery, critical care (pubmed 26963326) and more recently anaesthesia (PubMed 31025706), most studies have been found to be “fragile”.
I have numerous problems with the fragility index. For starters, RCTs are generally powered for a minimum clinically important difference. So studies by definition should be “fragile” under this definition, or the study recruited more patients than was necessary to answer the question at hand (and hence one could argue, was unethical).
This method appears to be gaining momentum, particularly in anaesthesia and critical care. I would be very interested to hear what this community has to comment on the fragility index. Of course if I am wrong, then I would be happy to be educated and change my position.