Is the interaction between Clinical Researchers and Statisticians working? My insight after reading four failed clinical trials on immunotherapy

I don’t believe in Bayes factors as measures of evidence, and it’s hard to apply them other than for a one-dimensional parameter. Instead, you can calculate Bayesian posterior probabilities from a two-treatment-parameter proportional hazards model:

  • P(the two survival curves differ at any time t)
  • P(the hazard functions differ at a specify time t)
  • P(treatment effect is accelerating over time)
  • P(treatment effect changes directions over time)
2 Likes