Due to the controversial results obtained in this secondary analysis of the SPRINT study, new analyzes are required, using other statistical approaches to validate our results. (Triangulation approach). In this sense, Rizopoulos et al have recently published a new analysis of the effect that SAEs have on the composite outcome of the SPRINT study, using a more flexible joint model and reaching similar conclusions.
https://onlinelibrary.wiley.com/doi/full/10.1002/sim.8387
Finally, I want to insist that The joint modeling approach does not condition on systolic blood pressure (SBP) after randomization but rather treats it as an outcome in the linear mixed model. So, SBP is not considered a classical mediator (Figure 2 in this forum discusion).