A recent study addressing a very fundamental question of considerable importance to the emergency room physician demonstrates the failure of the statistics applied using “Threshold Science” to progress the science toward an answer. Here, the question of the utility of the band count dates back tot the turn of the century. This question is asked here.
The fundamental controversy is .
Are the presence of an elevated absolute band count and/or elevated % bands in blood predictive of excess adverse events or death. (Bands are immature neutrophils which are only one level less mature than mature neutrophils).
Here is a 2021 study seeking to ask that question using “Threshold Science” in Pediatric patients:
Note they define bandemia as 10% (which is the “SIRS criteria” guessed in 1991) and “severe bandemia” as 2X 10% (Also guessed). Of course this is 20th Century “Threshold Science” as these are guessed thresholds (likely based on the 20th century “go metric” campaign not human physiology). 10 is the number of fingers on a human and has nothing to do with human leukocyte or apnea quantification.
Remember that in the failed (but still extant) Threshold Science of sleep apnea, an apnea is 10 seconds long and a hypopnea is 10 seconds long and in the original consensus if the sum (AHI) of the apnea and hypopnea is greater than 10 then the patient has sleep apnea. This threshold sum (AHI) was later changed to 5. Why was an apnea, hypopnea, a band %, and the AHI sum all equal to 10? You guessed it.
In stark contrast we see this exciting 2021 study which ignores the guessed consensus thresholds and abandons threshold science.
Remember Threshold Science is a failed 20th century “science” which uses guessed consensus thresholds comprising such storied 20th century measurements such as SOFA, SIRS and the AHI as entry criteria, dependent variable, or endpoint. and sometimes two of these at the same time.
“Threshold Science” cannot progress the true science over time to answer its own pivotal fundamental questions. In that regard, Threshold Science fails to deliver the fundamental function of science, the progression toward truth.