I abhor this sentiment. We need small, theoretically substantive trials capable of advancing medical science rapidly in a mode of strong inference. We do not need large, theoretically shallow trials that grope blindly* for small-effect-size metaphorical ‘oomphs’ that lack realistic theoretical connections to physiology.
- Cf. #amoEBMism:
https://twitter.com/davidcnorrismd/status/1204744657659297792