Discussion of Assessing Heterogeneity of Treatment Effect, Estimating Patient-Specific Efficacy, and Studying Variation in Odds ratios, Risk Ratios, and Risk Differences

[R_cubed]

There is this mega thread on the issue with lots of references:

Should one derive risk difference from the odds ratio?

This paper (Doi et al. 2020) came out last year heavily advocating for the odds ratio (OR). https://www.jclinepi.com/article/S0895-4356(20)31171-9/fulltext I am aware of OR’s advantages over risk ratio (RR), but I have heard mixed thoughts regarding how to derive risk difference (RD). For example, this paper from the GRADE group explains derivation from both OR and RR (https://www.jclinepi.com/article/S0895-4356(12)00032-7/abstract). They do not clearly say that one should derive the RD from R…